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leukemia

Leukemia is a group of malignant blood cancers originating from hematopoietic stem cells in the bone marrow, leading to abnormal proliferation of white blood cells and affecting the production and function of normal blood cells. Leukemia can be classified into acute leukemia (AML, ALL) and chronic leukemia (CML, CLL), with acute leukemia progressing rapidly and chronic leukemia progressing more slowly.

High-risk factors include:

  • Age: Acute leukemia is more common in children and adolescents, while chronic leukemia is more common in middle-aged and older adults.

  • Genetic factors: Chromosomal abnormalities or a family history of leukemia.

  • Environmental factors: Long-term exposure to radiation, benzene, or other chemicals.

  • Previous diseases or treatments: Such as long-term bone marrow suppression, chemotherapy, or radiotherapy.

  • Immune system abnormalities: Some congenital immune deficiencies increase the risk.

Symptoms of leukemia often arise from impaired function of normal blood cells and vary depending on the type:

  • Anemia: Fatigue, dizziness, palpitations.

  • Frequent infections: Increased susceptibility to bacterial, viral, or fungal infections due to reduced normal white blood cell function.

  • Bleeding tendencies: Gum bleeding, nosebleeds, subcutaneous bruising, or petechiae.

  • Enlarged lymph nodes, liver, or spleen.

  • Bone or joint pain: Caused by bone marrow involvement.

  • Fever and weight loss: General systemic symptoms.

  • Advanced symptoms: Organ dysfunction, severe anemia, or infection-related complications.

Because the symptoms are diverse and non-specific, early detection is especially important for high-risk individuals.

Diagnosis of leukemia relies on hematologic and bone marrow examinations:

Blood tests

  • Complete blood count (CBC) and blood smear.

  • Abnormal white blood cells, low platelets, or anemia may indicate leukemia.

Bone marrow examination

  • Bone marrow aspiration and biopsy confirm the type of leukemia cells.

  • Assess the extent of bone marrow involvement and classify the leukemia.

Molecular and genetic testing

  • Chromosome analysis and gene mutation testing.

  • Assist in classification, prognosis evaluation, and formulation of personalized care plans.

Imaging studies

  • Evaluate organ involvement or lymph node enlargement.

  • Includes CT, ultrasound, or MRI.

 
 

Management of leukemia includes chemotherapy, bone marrow transplantation, targeted/immunotherapy support, and personalized care, aiming to control disease progression, improve quality of life, and reduce complications:

Chemotherapy

  • Treatment plans are selected based on leukemia type and stage.

  • Supportive care helps reduce side effects and maintain energy levels.

Bone Marrow / Stem Cell Transplantation

  • Suitable for high-risk or relapsed patients.

  • Combined with supportive care and nutrition to promote recovery.

Targeted and Immunotherapy Support

  • Medications targeting specific genetic or molecular abnormalities.

  • Personalized care plans can enhance immune function and treatment tolerance.

Nutritional and Supportive Therapies

  • High-dose vitamin C, amino acids, glutathione, and trace element infusions.

  • Improve energy levels, support immune function, and maintain overall health.

Personalized Monitoring and Care

  • Regular blood and bone marrow tests to monitor disease progression.

  • Adjust care plans, nutrition, lifestyle, and psychological support as needed.

  • High-risk or advanced patients may receive specialized care programs.

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