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Endometrial cancer (uterine body cancer)

Endometrial cancer is one of the most common malignancies of the female reproductive system, primarily originating from the uterine lining. It mainly occurs in peri- and postmenopausal women, although some high-risk younger women may also develop the disease.

Major Risk Factors Include:

  • Hormonal Factors: Prolonged estrogen exposure (e.g., estrogen therapy without progesterone), early menarche, or late menopause.

  • Metabolic Factors: Higher incidence in women with obesity, diabetes, or hypertension.

  • Reproductive and Medical History: Infertility, nulliparity, and polycystic ovary syndrome (PCOS) increase risk.

  • Genetic Factors: Familial adenocarcinoma or hereditary nonpolyposis colorectal cancer (HNPCC/Lynch syndrome) may elevate risk.

Early detection is crucial for improving quality of life and health management. Ongoing health monitoring and supportive care are key to ensuring long-term well-being for patients.

Early-stage endometrial cancer symptoms are often related to abnormal bleeding, and may include:

  • Abnormal Vaginal Bleeding: Postmenopausal bleeding is a typical warning sign. In premenopausal women, this may present as irregular menstruation or abnormal menstrual flow.

  • Lower Abdominal or Pelvic Discomfort: Including dull pain, a sense of pressure, or abdominal heaviness.

  • Urinary or Bowel Changes: In advanced stages, tumor compression may cause frequent urination, constipation, or difficulty with bowel movements.

  • Weight Loss or Decreased Appetite: May indicate disease progression or chronic consumption.

  • Abdominal Mass or Ascites: Can occur in advanced stages, suggesting tumor invasion or metastasis.

Additionally, some patients may experience chronic fatigue, lower back soreness, or leg swelling, warranting comprehensive evaluation.

Diagnosis relies on multiple methods to improve early detection and accurate staging:

  • Imaging Studies

    • Transvaginal Ultrasound: Evaluates endometrial thickness, tumor size, and morphology.

    • CT or MRI: Assesses tumor invasion depth and pelvic/abdominal metastasis.

  • Pathological Examination

    • Endometrial biopsy or curettage to determine cancer type and degree of differentiation.

  • Tumor Markers

    • Markers such as CA-125 can assist in diagnosis and postoperative monitoring.

  • Molecular and Genetic Testing

    • For high-risk families or specific subtypes, genetic testing aids in designing personalized care plans.

Care and support strategies can be divided into traditional approaches and personalized support strategies, aiming to slow disease progression, maintain quality of life, and enhance physical resilience:

  • Surgery

    • Suitable for early-stage tumors; may involve removal of the uterus and adnexa, and lymph node dissection if necessary.

    • Postoperative care with nutritional support, physical rehabilitation, and psychological counseling can promote recovery and daily function restoration.

  • Radiation or Chemotherapy Support

    • Applied in mid-to-late stage or high-risk recurrence patients to control tumor growth and reduce recurrence risk.

    • Combined with nutritional management, fluid balance, and care guidance to minimize side effects and maintain bodily function.

  • Personalized Support Strategies

    • Care plans are tailored based on pathological subtype, stage, and molecular testing results.

    • Incorporates immune support and lifestyle management to enhance overall health and resilience.

  • Nutritional and Supportive Therapies

    • High-dose Vitamin C, glutathione, amino acids, and trace element IV therapy can improve energy levels, maintain immune function, and support recovery.

    • Balanced diet, weight control, and lifestyle adjustments are recommended to reduce metabolic risks.

  • Personalized Monitoring and Care

    • Regular imaging, blood tests, and molecular marker assessments to monitor tumor status.

    • Personalized care plans adjust nutrition, lifestyle, and psychological support.

    • Special care strategies are provided for patients with chronic inflammation, metabolic abnormalities, or impaired immunity to enhance long-term quality of life.

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